3.8 Article

Slowly activating voltage-gated potassium current potentiation by ML277 is a novel cardioprotective intervention

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Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277

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Summary: The KCNQ1 ion channel plays critical roles in various organs and its loss of function leads to severe diseases. Researchers have used cryo-EM to determine the structure of KCNQ1 bound to ML277 and identified the binding site. These findings provide insights into the mechanism of the activator and potential therapeutic interventions for KCNQ1 loss of function pathologies.

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