Journal
TRANSPLANT IMMUNOLOGY
Volume 81, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.trim.2023.101916
Keywords
Stem cell transplantation; Graft-versus-host disease; Immune reconstitution inflammatory syndrome; Neuroinflammation
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Transplant physicians should be aware of immune deviation-related clinical conditions in allogeneic hematopoietic stem cell transplantation. Diagnosis of immune reconstitution inflammatory syndrome (IRIS) in patients with chronic graft-versus-host disease (GVHD) poses challenges due to overlapping clinical immunological conditions.
Transplant physicians should be aware of the immune deviation-related clinical conditions as allogeneic hematopoietic stem cell transplantation is widely used for the treatment of patients with malignant and nonmalignant disorders. Neurological manifestations and graft-versus-host disease (GVHD) may commonly develop in transplant recipients. However, overlapping clinical immunological conditions may lead to diagnostic challenges. Herein, we discussed the differential diagnosis of a patient with immune reconstitution inflammatory syndrome (IRIS) developing on the basis of chronic GVHD.
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