Journal
CHEMICAL COMMUNICATIONS
Volume 59, Issue 74, Pages 11077-11080Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc03058j
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A novel, straightforward, and scalable base-mediated one-pot three-component desulphurization cross-coupling strategy is reported for the synthesis of 4-cyanoimidazole derivatives. Over 35 examples are provided and achieved yields exceeding 85%. Notably, the majority of these readily available compounds can be isolated through simple filtration, thereby circumventing the need for laborious column chromatography.
A novel, straightforward, and scalable base-mediated one-pot three-component desulphurization cross-coupling strategy is reported for the synthesis of 4-cyanoimidazole derivatives. Over 35 examples are provided and achieved yields exceeding 85%. Notably, the majority of these readily available compounds can be isolated through simple filtration, thereby circumventing the need for laborious column chromatography. Besides, the present protocol can be scaled up to 10 mmol with a yield of 87%, demonstrating promising potential for industrial applications. Herein, we present a pioneering, facile, and scalable base-mediated one-pot three-component desulphurization cross-coupling strategy for the synthesis of 4-cyanoimidazole derivatives.
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