4.6 Article

Palladium-catalyzed reductive Heck-type vinylative dearomatization of unfunctionalized halonaphthalene derivatives

Journal

RSC ADVANCES
Volume 6, Issue 102, Pages 100632-100635

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra22310a

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Funding

  1. National Natural Science Foundation of China [21502174, 21502175]
  2. Beijing National Laboratory for Molecular Sciences [20140105]
  3. Startup Research Fund of Zhengzhou University [1411316005]
  4. Scientific Research Fund of Henan Provincial Education Department [15A150080]

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A novel strategy for the dearomatization of inactive 1-halonaph-thalenes via palladium-catalyzed reductive Heck-type vinylative reaction was successfully developed. Both homo- and hetero-cyclic naphthalene derivatives were tolerated, and the desired products were obtained in modest to good yields.

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