Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 145, Issue 36, Pages 19503-19507Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.3c06260
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Tile-based DNA self-assembly is a versatile method for constructing a wide range of nanostructures for various applications. By designing DNA tiles containing both ligands and aptamers, geometrically well-defined nanostructures can be formed upon ligand-aptamer binding. This new inter-tile cohesion could open up new potentials for DNA self-assembly, allowing modulation of nanostructure formation through the addition of free ligands.
Tile-based DNA self-assembly provides a versatile approach for the construction of a wide range of nanostructures for various applications such as nanomedicine and advanced materials. The inter-tile interactions are primarily programmed by base pairing, particularly Watson-Crick base pairing. To further expand the tool box for DNA nanotechnology, herein, we have designed DNA tiles that contain both ligands and aptamers. Upon ligand-aptamer binding, tiles associate into geometrically well-defined nanostructures. This strategy has been demonstrated by the assembly of a series of DNA nanostructures, which have been thoroughly characterized by gel electrophoresis and atomic force microscopy. This new inter-tile cohesion could bring new potentials to DNA self-assembly in the future. For example, the addition of free ligand could modulate the nanostructure formation. In the case of biological ligands, DNA self-assembly could be related to the presence of certain ligands.
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