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INORGANIC CHEMISTRY FRONTIERS
Volume -, Issue -, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3qi00932g
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We report the mechanochemically-induced deuteration of aromatic C(sp(2))-H bonds activated by Pd at ambient temperature without the need for solvents. Deuterium was sourced from cysteine-d(4) to obtain mono- or dideuterated products from different aromatic palladacycles. Besides the high deuteration yields, we provide a detailed view of the reaction course in the solid state through time-resolved in situ Raman monitoring and DFT calculations. The obtained knowledge could lead to the broader application of this methodology for the deuteration of organic compounds.
We report mechanochemically-induced deuteration of Pd-activated aromatic C(sp(2))-H bonds at ambient temperature under solvent-free conditions. Deuterium was sourced from cysteine-d(4) to obtain mono- or dideuterated products from various aromatic palladacycles. Next to good deuteration yields, based on time-resolved in situ Raman monitoring and DFT calculations, we present a detailed view of the reaction course in the solid state. The obtained knowledge could lead to the broader application of this methodology for the deuteration of organics.
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