Journal
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
Volume 29, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/10760296231201855
Keywords
vitamin d; hemostasis; blood coagulation; plasminogen activator inhibitor 1; plasminogen activator inhibitor 2; pregnancy
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Vitamin D deficiency is associated with an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio in pregnant women, which may increase thrombotic risk and lead to pregnancy complications. Further research is needed to determine the optimal vitamin D supplementation in pregnancy.
BackgroundVitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk. However, pregnant women are commonly excluded from studies investigating the hemostatic system, and knowledge on the impact of vitamin D on hemostasis in pregnancy is therefore limited.MethodsA cross-sectional study comparing the hemostatic profile of pregnant women (gestational week 12.9 & PLUSMN; 0.7) with vitamin D deficiency (& LE;50 nmol/L) (n = 70) and high adequate vitamin D status (& GE;100 nmol/L) (n = 59).ResultsVitamin D deficient women displayed increased plasminogen activator inhibitor 1 levels and an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio, even after adjusting for factors with potential influence on hemostasis (body mass index, smoking and use of fish oil supplements).ConclusionsVitamin D deficiency is associated with increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio in pregnant women. As an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio with high plasminogen activator inhibitor 1 levels may increase thrombotic risk and is associated with the development of pregnancy complications, further research is needed to determine the optimal vitamin D supplementation in pregnancy.
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