Journal
RSC ADVANCES
Volume 6, Issue 50, Pages 44279-44287Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra04066g
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Funding
- Czech Science Foundation [16-15020S]
- Grant Agency of the Charles University in Prague [252216]
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Novel non-toxic materials with antimicrobial surfaces are needed for medicinal applications. Potential alternatives for bacterial inactivation include materials that produce singlet oxygen, O-2((1)Delta(g)), a short-lived, highly oxidative, and cytotoxic species. We synthesized a promising group of materials, porphyrin-based conjugated microporous polymers (CMPs), which effectively generate O-2((1)Delta(g)) under visible light irradiation. CMPs were rationally designed and synthesized to maximize O-2((1)Delta(g)) production. A strategy based on three-dimensional frameworks allowed the immediate environment of the porphyrin units to be tuned and their structure-property relationships to be elucidated. We investigated the photophysical and photochemical properties of the frameworks and compared them with the properties of porphyrin-based CMPs and metal-organic frameworks. In general, the O-2((1)Delta(g)) production activity of the CMPs correlated with neither the surface area nor with the pore volume. The novel CMPs displayed high O-2((1)Delta(g)) production, were stable in organic solvents, and did not undergo measurable photobleaching.
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