Journal
RSC ADVANCES
Volume 6, Issue 22, Pages 18419-18451Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra23908g
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- ALMA MATER STUDIORUM Universita di Bologna
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Chiral, either racemic or optically pure, substituted cyclohexanes, piperidines, tetrahydrofurans and pyrrolidines can be prepared by the diastereoselective hydrogenation/reduction of the corresponding aromatic and heteroaromatic precursors, exploiting the presence of one or more stereocenters present in the ring substituent(s), where the sense and level of asymmetric induction can be the result of different factors: the rigidity or flexibility of the substrate, the presence of an appropriate functionality in the lateral substituent which can stabilize a particular conformation of the molecule, especially in pyridine and furan derivatives, the nature of the catalyst or the reducing system, and the experimental conditions.
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