Journal
RSC ADVANCES
Volume 6, Issue 86, Pages 82716-82720Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra19790f
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Funding
- Aichi Science & Technology Foundation
- JSPS KAKENHI [JP 16H01142]
- Platform Project for Supporting in Drug Discovery and Life Science Research (Platform for Drug Discovery, Informatics, and Structural Life Science) from Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [16H01142] Funding Source: KAKEN
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The Ruppert-Prakash reagent is the most powerful and well-documented reagent for trifluoromethylation. Despite its versatility, no general method exists for its use in a flow system. Here we report the first flow trifluoromethylation of carbonyl compounds and its utility for drug synthesis of efavirenz and HSD-016, including preliminary results of enantioselective variants.
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