Journal
RSC ADVANCES
Volume 6, Issue 56, Pages 50780-50785Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra05015h
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A method of palladium catalysed efficient alkynylation through the cross coupling reaction of terminal alkynes with the slightly more acidic C-H bonds of 4-thiazolidinone has been developed. This method allows the direct introduction of an ethynyl group into the 4-thiazolidinone moiety. Mild reaction conditions involving aerial oxidation and one pot synthesis make this reaction more efficient for the formation of sp(3)(C)-sp(C) bond.
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