4.6 Article

Diselenide-based probe for the selective imaging of hypochlorite in living cancer cells

Journal

RSC ADVANCES
Volume 6, Issue 38, Pages 32013-32017

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra04257k

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Funding

  1. Mid-Career Researcher Program through the NRF (National Research Foundation) of Korea - MEST [NRF-2014R1A2A1A11052980]
  2. Institute for Basic Science (IBS)
  3. IBS

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A non-traditional and robust probe skeleton was derivatized for chemosensing applications to investigate a potential novel mode of hypochlorite detection. The BDPP-DSe probe gave a similar to 180-fold turn-on response to hypochlorite. Confocal fluorescence imaging demonstrated detection of hypochlorite in living cells and cell membrane permeability.

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