In situ remineralizing effect of fluoride varnishes containing sodium trimetaphosphate

Objective This study analyzed the effects of a fluoride (F) varnish supplemented with sodium trimetaphosphate (TMP) on the remineralization of caries-like lesions in situ. Materials and methods Twelve subjects used palatal devices with demineralized enamel discs for 3 days, following a double-blind, crossover protocol. Test groups included placebo (no F or TMP), 5 % NaF and 5 % NaF/5 % TMP varnishes. The percentage of surface hardness recovery (%SHR) and cross-sectional hardness (Delta KHN) were determined. Results Significant differences were observed among all varnishes regarding %SHR and Delta KHN. The highest %SHR and the lowest Delta KHN were seen for the 5 % NaF/5 % TMP varnish, followed by 5 % NaF and placebo. Conclusions The remineralizing effect of a 5 % NaF varnish is significantly enhanced when associated with TMP.