Journal
RSC ADVANCES
Volume 6, Issue 7, Pages 5936-5943Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra24222c
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Funding
- National Science Centre [UMO-2014/13/D/ST5/02793]
- National Centre for Research and Development [PBS1/A9/13/2012]
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Magnetic nanoparticles (MNP) coated with bioinspired polydopamine (PDA) were obtained via a co-precipitation method and oxidative polymerization of dopamine. Nanoparticles were investigated by FTIR, TEM and SQUID. Loading capacity of anticancer drug doxorubicin was determined by UV-Vis spectroscopy. The nanocomposites exhibit a high drug loading capacity of 0.46 mg mg(-1). Anticancer activity of the nanocomposites was proved in profound in vitro tests on HeLa cells. Cytotoxicity and internalization of nanoparticles were checked using various method, i.e. proliferation assay (WST-1), a two-colour fluorescence cell viability assay, and fluorescent and confocal microscopy.
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