Journal
RSC ADVANCES
Volume 6, Issue 76, Pages 72586-72595Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra10994b
Keywords
-
Categories
Funding
- European Union from the resources of the European Regional Development Fund under the Innovative Economy Programme [POIG.01.01.02-00-69/09]
- European Regional Development Fund in the framework of the Polish Innovation Economy Operational Programme [POIG.02.01.00-12-023/08]
- National Science Centre, Poland [2012/07/B/ST8/03109]
Ask authors/readers for more resources
This study aimed to develop superparamagnetic iron oxide nanoparticles (SPIONs) targeted to the areas of vascular endothelium changed in the initial inflammation process, a first step of numerous cardiovascular diseases. Iron oxide nanoparticles coated with a cationic derivative of chitosan (CCh) and having attached monoclonal antibodies (anti VCAM-1 and anti P-selectin) were successfully prepared. Owing to electrostatic stabilization, they form a stable colloidal dispersion in aqueous media. The superparamagnetic properties of the resulting SPION-CCh-anti-VCAM-1 maghemite nanoparticles were proved by magnetometric and Mossbauer measurements. In vitro studies confirmed the specific interaction of anti-VCAM-1 antibodies bound to the surface of SPIONs with endothelial cells of aorta of db/db mice, known to display endothelial inflammation associated with diabetes. The nanoparticles obtained were also visualized using MRI in the aortic arch of ApoE/LDLR-/-mice displaying endothelial inflammation associated with atherosclerosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available