Journal
ONCOTARGET
Volume 7, Issue 41, Pages 66944-66958Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11396
Keywords
berberine; glioblastoma; autophagy; apoptosis; metabolism
Categories
Funding
- Natural Science Foundation of China [81402060, 81572487]
- Special Foundation for Taishan Scholars [ts20110814, tshw201502056]
- Shandong Provincial Science & Technology Major Project (emerging industry) [2015ZDXX0801A01]
- Fundamental Research Funds of Shandong University [2015QY001]
- Key Research & Development Program of Shandong Province [2015GSF118074, 2015GGE27101]
- University of Bergen
- Helse Bergen, Norway
- Norwegian Centre for International Cooperation in Education (SIU) [UTF-2014/10047]
Ask authors/readers for more resources
There is an urgent need for new therapeutic strategies for patients with glioblastoma multiforme (GBM). Previous studies have shown that berberine (BBR), a natural plant alkaloid, has potent anti-tumor activity. However, the mechanisms leading to cancer cell death have not been clearly elucidated. In this study, we show that BBR has profound effects on the metabolic state of GBM cells, leading to high autophagy flux and impaired glycolytic capacity. Functionally, these alterations reduce the invasive properties, proliferative potential and induce apoptotic cell death. The molecular alterations preceding these changes are characterized by inhibition of the AMPK/mTOR/ULK1 pathway. Finally, we demonstrate that BBR significantly reduces tumor growth in vivo, demonstrating the potential clinical benefits for autophagy modulating plant alkaloids in cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available