Journal
ONCOTARGET
Volume 7, Issue 34, Pages 55828-55839Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10094
Keywords
B lymphocytes; regulatory B cells; tumor-infiltrating B cells; tumor; tumor immunotherapy
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Funding
- National Natural Science Foundation of China [81272221, 81201561, 81472471]
- National Basic Research Program of China [2012CB933304]
- Tianjin Natural Science Foundation [13JCQNJC10400]
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Accumulating evidence indicated that B lymphocytes exerted complex functions in tumor immunity. On the one hand, B lymphocytes can inhibit tumor development through antibody generation, antigen presentation, tumor tissue interaction, and direct killing. On the other hand, B lymphocytes have tumor-promoting functions. A typical type of B lymphocytes, termed regulatory B cells, is confirmed to attenuate immune response in a tumor environment. In this paper, we summarize the current understanding of B-cell functions in tumor immunology, which may shed light on potential therapeutic strategies against cancer.
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