Journal
ONCOTARGET
Volume 7, Issue 29, Pages 44879-44905Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.9821
Keywords
oxidative stress; mitochondrial dysfunction; ROS; aging; cancer; Gerotarget
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Funding
- Russian Foundation for Basic Research [16-04-01521a, 15-34-70035 mol_a_mos]
- Russian Federation [MK-8047.2016.4]
- RAS Presidium Program Molecular and Cellular Biology
- ICGEB [CRP/RUS15-01]
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Aging and cancer are the most important issues to research. The population in the world is growing older, and the incidence of cancer increases with age. There is no doubt about the linkage between aging and cancer. However, the molecular mechanisms underlying this association are still unknown. Several lines of evidence suggest that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes. Increasing ROS levels and products of the oxidative stress, which occur in aging and age-related disorders, were also found in cancer. This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype.
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