Journal
ONCOTARGET
Volume 7, Issue 34, Pages 54174-54182Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11099
Keywords
long noncoding RNA MIAT; chronic lymphocytic leukemia; Non-Hodgkin's lymphoma; OCT4; cell apoptosis
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Funding
- National Institutes of Health of the CLL Research Consortium [PO1-CA81534]
- [R35-CA197706]
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Long noncoding RNAs (lncRNAs) are non-proten-coding transcripts of more than 200 nucleotides generated by RNA polymerase II and their expressions are tightly regulated in cell type specific- and/or cellular differential stage specific-manner. MIAT, originally isolated as a candidate gene for myocardial infarction, encodes lncRNA (termed MIAT). Here, we determined the expression level of MIAT in established leukemia/lymphoma cell lines and found its upregulation in lymphoid but not in myeloid cell lineage with mature B cell phenotype. MIAT expression level was further determined in chronic lymphocytic leukemias (CLL), characterized by expansion of leukemic cells with mature B phenotype, to demonstrate relatively high occurrence of MIAT upregulation in aggressive form of CLL carrying either 17p-deletion, 11q-deletion, or Trisomy 12 over indolent form carrying 13p-deletion. Furthermore, we show that MIAT constitutes a regulatory loop with OCT4 in malignant mature B cell, as was previously reported in mouse pulripotent stem cell, and that both molecules are essential for cell survival.
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