Journal
ONCOTARGET
Volume 7, Issue 35, Pages 57391-57413Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10548
Keywords
necroptosis; tumorigenesis; anti-tumor immune; cancer therapy
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Funding
- National Natural Science Foundation of China [81301624, 81201754, 81472797]
- New Teacher Fund for Doctor Station
- Ministry of Education [20121202120014]
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While the mechanisms underlying apoptosis and autophagy have been well characterized over recent decades, another regulated cell death event, necroptosis, remains poorly understood. Elucidating the signaling networks involved in the regulation of necroptosis may allow this form of regulated cell death to be exploited for diagnosis and treatment of cancer, and will contribute to the understanding of the complex tumor microenvironment. In this review, we have summarized the mechanisms and regulation of necroptosis, the converging and diverging features of necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy, as well as attempts to exploit this newly gained knowledge to provide therapeutics for cancer.
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