Journal
ONCOTARGET
Volume 8, Issue 2, Pages 3649-3665Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.12278
Keywords
MDSC origin; myelopoiesis; emergency myelopoiesis; reprogramming; extramedullary
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Funding
- Vetenskapsradet
- Cancerfonden
- Osterlunds Foundation
- Gunnar Nilsson Cancer Foundation
- MAS Cancer Foundation
- Ake Wibergs Foundation
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Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. In cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs). The classical definition of MDSCs as immature myeloid cells blocked from differentiating has been challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent monocytes and granulocytes that have acquired immunosuppressive properties. The molecular mechanism behind their generation and their true origins are now widely debated. In this review we discuss the different proposed mechanisms of the generation of both types of MDSCs, with a special focus on human MDSCs in cancer.
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