Journal
ONCOTARGET
Volume 7, Issue 12, Pages 14522-14536Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.7392
Keywords
miR-15a; gastric cancer; Bmi-1; survival
Categories
Funding
- National Natural Science Foundation of China [81301960, 81171653]
- National Key Technology RD Program [2015BAI12B12]
- National Clinical Research Center for Cancer
- Natural Science Foundation of Jiangsu Province [BK2011246, BK2011247]
- Project of Six Batch of Major Talent Summit [BRA2010037]
- Jiangsu Key Laboratory of Medical Science and Laboratory Medicine [JSKLM-2014-003]
- Society development plans, Department of Science and Technology Changzhou [CJ20112020, CZ20110024, CS20102020]
- Innovative Talents Training Project of Changzhou Health Bureau
- National Cancer Institute [R01CA155019, R33CA147966]
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B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays important roles in gastric cancer, but the epigenetic regulatory mechanism by microRNA (miRNA) and the functional significance of Bmi-1 inhibition in gastric cancer remains elusive. In this study, we systematically investigated the functional roles of miRNA mediated Bmi-1 suppression in gastric cancer. Our results show that the expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. Functional studies revealed that ectopic expression of miR-15a decreased Bmi-1 in gastric cancer cell lines with reduced proliferation and tumor invasion. High levels of Bmi-1 in gastric cancer patients are significantly associated with better overall survival (P = 0.024) based on the Kaplan-Meier survival analysis.
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