Journal
ONCOTARGET
Volume 7, Issue 35, Pages 57367-57378Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10350
Keywords
local hyperthermia; head and neck cancer; heat shock proteins (HSPs); nanoparticle; near-infrared (NIR)
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Funding
- National Natural Science Foundation of China [81361120399, 81272961, 81372891, 81572650]
- State Key Laboratory of Oral Diseases Special Funded Projects [SKLOD201512]
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Local hyperthermia (HT), particularly in conjunction with surgery, radiotherapy and chemotherapy was useful for the treatment of human malignant tumors including head and neck cancer. However, at present it suffered from many limitations such as thermal dose control, target treatment regions and discrimination between healthy and cancer cells. Recent developments in nanotechnology have introduced novel and smart therapeutic nanomaterials to local HT of head and neck cancer that basically take advantage of various targeting approaches. The aim of this paper is to give a brief review of the mechanism, methods and clinical applications of local HT in head and neck cancer, mainly focusing on photothermal therapy (PTT) and nanoparticlebased hyperthermia.
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