Journal
ONCOTARGET
Volume 7, Issue 17, Pages 23785-23800Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8122
Keywords
LL-37; calcium signaling; membrane association; cell migration; breast cancer
Categories
Funding
- Region Centre-Val de Loire
- University of Tours, INSERM
- Ligue Contre le Cancer
- ARD2020 Biomedicaments
- Ministere de l'Enseignement Superieur et de la Recherche
Ask authors/readers for more resources
Expression of the antimicrobial peptide hCAP18/LL-37 is associated to malignancy in various cancer forms, stimulating cell migration and metastasis. We report that LL-37 induces migration of three cancer cell lines by activating the TRPV2 calcium-permeable channel and recruiting it to pseudopodia through activation of the PI3K/AKT pathway. Ca2+ entry through TRPV2 cooperated with a K+ efflux through the BKCa channel. In a panel of human breast tumors, the expression of TRPV2 and LL-37 was found to be positively correlated. The D-enantiomer of LL-37 showed identical effects as the L-peptide, suggesting that no binding to a specific receptor was involved. LL-37 attached to caveolae and pseudopodia membranes and decreased membrane fluidity, suggesting that a modification of the physical properties of the lipid membrane bilayer was the underlying mechanism of its effects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available