Journal
ONCOTARGET
Volume 7, Issue 27, Pages 42716-42739Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8446
Keywords
DHX9; helicase; RNA helicase A; DExD/H-box; Maleless
Categories
Funding
- National Institutes of Health [CA163291]
- Canadian Institutes of Health Research [MOP-115126]
- Maysic MacSporran graduate studentship
- CIHR-sponsored Chemical Biology and Systems Biology Training Programs
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DHX9 is member of the DExD/H-box family of helicases with a DEIH sequence at its eponymous DExH-box motif. Initially purified from human and bovine cells and identified as a homologue of the Drosophila Maleless (MLE) protein, it is an NTP-dependent helicase consisting of a conserved helicase core domain, two double-stranded RNA-binding domains at the N-terminus, and a nuclear transport domain and a single-stranded DNA-binding RGG-box at the C-terminus. With an ability to unwind DNA and RNA duplexes, as well as more complex nucleic acid structures, DHX9 appears to play a central role in many cellular processes. Its functions include regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. Because of its central role in gene regulation and RNA metabolism, there are growing implications for DHX9 in human diseases and their treatment. This review will provide an overview of the structure, biochemistry, and biology of DHX9, its role in cancer and other human diseases, and the possibility of targeting DHX9 in chemotherapy.
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