Journal
ONCOTARGET
Volume 8, Issue 5, Pages 8900-8909Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13051
Keywords
gamma delta T cells; immunotherapy; anti-tumor; cancer treatment
Categories
Funding
- Scientific and Technology Foundation of Guangdong Province [2015B090904007]
- Natural Science Foundation of Guangdong Province [2015A030313829]
- Science and Technology Foundation of Shenzhen [CXZZ20150430092951135, KQTD20140630100658078]
- Natural Science Foundation of SZU [201573]
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gamma delta T cells are one of the three immune cell types that express antigen receptors. They contribute to lymphoid antitumor surveillance and bridge the gap between innate and adaptive immunity. gamma delta T cells have the capacity of secreting abundant cytokines and exerting potent cytotoxicity against a wide range of cancer cells. gamma delta T cells exhibit important roles in immune-surveillance and immune defense against tumors and have become attractive effector cells for cancer immunotherapy. gamma delta T cells mediate anti-tumor therapy mainly by secreting pro-apoptotic molecules and inflammatory cytokines, or through a TCR-dependent pathway. Recently, gamma delta T cells are making their way into clinical trials. Some clinical trials demonstrated that gamma delta T cell-based immunotherapy is well tolerated and efficient. Despite the advantages that could be exploited, there are obstacles have to be addressed for the development of gamma delta T cell immunotherapies. Future direction for immunotherapy using gamma delta T cells should focus on overcoming the side effects of gamma delta T cells and exploring better antigens that help stimulating gamma delta T cell expansion in vitro.
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