Journal
ONCOTARGET
Volume 7, Issue 22, Pages 32478-32492Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8744
Keywords
ANRIL; proliferation; cell cycle; apoptosis; senescence
Categories
Funding
- National Natural Science Foundation of China [81370689, 81571404, 81502240, 81502049, 81402152]
- Shanghai Sailing Program [15YF1401400]
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Antisense non-coding RNA in the INK4 locus (ANRIL) has been implicated in a variety of cancers. In the present study, we evaluated ANRIL expression in epithelial ovarian cancer (EOC) and defined its clinical implications and biological functions. ANRIL was overexpressed in EOC tissues relative to normal controls. Overexpression correlated with advanced International Federation of Gynecologists and Obstetricians stage and high histological grade. Multivariate analysis indicated that ANRIL is an independent prognostic factor for overall survival in EOC. Gain-and loss-of-function experiments demonstrated that ANRIL promotes EOC cell proliferation both in vitro and in vivo. The proliferative effect was linked to the promotion of cell cycle progression and inhibition of apoptosis and senescence. Down-regulation of P15(INK4B) and up-regulation of Bcl-2 by ANRIL may partially explain ANRIL-induced EOC cell proliferation. This study is the first to establish that ANRIL promotes EOC progression and is a potential prognostic biomarker.
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