Journal
ONCOTARGET
Volume 8, Issue 5, Pages 8980-8991Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13858
Keywords
histone methylation; demethylases; KDM5B
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Funding
- Department of Health, Department of Healthcare of Ministry and Zhejiang [2015103070, WKJ-ZJ-1520]
- National Natural Science Foundation [81372178, 81572715]
- Fundamental Research Funds for the Central Universities [2016FZA7001]
- 151 talents program in Zhejiang
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Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation status take part in various physiological and pathological processes. KDM5B (lysine demethylase 5B, also called JARID1B or PLU-1) encodes the histone H3 lysine4 (H3K4) demethylase and exhibits a strong transcriptional repression activity. KDM5B plays a role in cell differentiation, stem cell self-renewal and other developmental progresses. Recent studies showed that KDM5B expression was increased in breast, bladder, lung, prostate and many other tumors and promotes tumor initiation, invasion and metastasis. Given its association with tumor progression and prognosis of cancer patients, KDM5B was proposed to be a novel target for the prevention and treatment of human cancers. In this review, we will summarize recent advances in our understanding of the regulation and function of KDM5B in development and cancer.
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