Journal
ONCOTARGET
Volume 8, Issue 4, Pages 7059-7067Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.12535
Keywords
c-myc; 3' regulatory region; lymphomagenesis; transgenic mice; HDAC
Categories
Funding
- Conseil Regional du Limousin
- Comite d'Orientation de la Recherche Cancerologie du Limousin [FJA/NP2015-109]
- Association pour la Recherche sur le Cancer [20141201649]
- Ligue Contre le Cancer (Comite de la Correze et Haute Vienne)
- Agence Nationale de la Recherche
- Lions Club de la Correze, Zone 33 district 103 Sud
- fondation ARC [DOC20150602943]
- Association de Specialisation et d'Orientation Scientifique (Lebanon)
- municipality of Khiam (Lebanon)
Ask authors/readers for more resources
Deregulation and mutations of c-myc have been reported in multiple mature B-cell malignancies such as Burkitt lymphoma, myeloma and plasma cell lymphoma. After translocation into the immunoglobulin heavy chain (IgH) locus, c-myc is constitutively expressed under the control of active IgH cis-regulatory enhancers. Those located in the IgH 3' regulatory region (3'RR) are master control elements of transcription. Over the past decade numerous convincing demonstrations of 3'RR's contribution to mature c-myc-induced lymphomagenesis have been made using transgenic models with various types of IgH-c-myc translocations and transgenes. This review highlights how IgH 3'RR physiological functions play a critical role in c-myc deregulation during lymphomagenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available