Journal
ONCOTARGET
Volume 7, Issue 41, Pages 67674-67684Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11874
Keywords
Wnt5a; beta-catenin; macrophage; angiogenesis; lymphangiogenesis
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Funding
- National Natural Science Foundation of China [81370517]
- Natural Science Foundation of Liaoning Province [2014021036]
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Wnt5a is implicated in development and tissue homeostasis by activating beta-catenin-independent pathway. Excessive production of Wnt5a is related to some human diseases. Macrophage recruitment is a character of inflammation and cancer, therefore macrophage-derived Wnt5a is supposed to be a player in these conditions. Actually, macrophage-derived Wnt5a maintains macrophage immune function, stimulates pro-inflammatory cytokine release, and induces angiogenesis and lymphangiogenesis. Furthermore, macrophage-derived Wnt5a is involved in insulin resistance, atherosclerosis and cancer. These findings indicate that macrophage-derived Wnt5a may be a target in the treatment of these diseases. Notably, unlike macrophages, the exact role of macrophage-derived Wnt5a in bacterial infection remains largely unknown.
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