Journal
ONCOTARGET
Volume 7, Issue 45, Pages 72546-72558Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.12466
Keywords
long noncoding RNAs; natural killer cells; CD56; primary lymphocytes; lnc-CD56; Immunology and Microbiology Section; Immune response; Immunity
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Funding
- key project of the National Natural Science Foundation of China [91442202, 81330071]
- National Natural Science Foundation of China [81571521, 31300715]
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Natural killer (NK) cells are innate immune lymphocytes that play critical roles in host defense against viral infection and surveillance against malignant transformation. Long noncoding RNAs (lncRNAs) are important immune system regulators. Here, we analyzed human primary lymphocyte lncRNA expression profiles to identify NK-lncRNA signatures. We detected numerous novel NK-specific lncRNAs with potential roles in regulating human NK cell differentiation and function. Expression of lnc-CD56, an NK-specific lncRNA, was positively correlated with that of CD56, a classical human NK cell surface marker. We showed that lnc-CD56 may function as a positive regulator of CD56 in primary human NK cells and differentiated NK cells from human CD34(+) hematopoietic progenitor cells. Our data provide an annotated human NK cell lncRNA expression catalog and demonstrate a key role for lncRNAs in NK cell biology.
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