Journal
ONCOTARGET
Volume 8, Issue 2, Pages 3666-3682Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.12343
Keywords
miRNAs regulatory signaling pathways; acute myeloid leukemia; pathogenesis; prognosis; miRNA-directed therapy
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Funding
- National Natural Science Foundation of China [81300426, 30771103, 81172792, 81573467, 81373670]
- project for Shandong Medical and Health Science and Technology Plan project [2013WS0365]
- Natural Science Foundation of Shandong Province of China [ZR2015YL028, 2015ZRC03102]
- twelfth five year National Science and Technology Support program [2013BAI07B02]
- Shandong key project for Transformation of Results with Independent Innovation [2014CGZH1313, 2013ZHZX2A0405]
- Project for Laureate of Taishan Scholar [ts201511075]
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MicroRNAs (miRNAs) are small, non-coding RNAs found throughout the eukaryotes that control the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells and tumorigenesis. Widespread dysregulation of miRNAs have been found in hematological malignancies, including human acute myeloid leukemia (AML). A comprehensive understanding of the role of miRNAs within the complex regulatory networks that are disrupted in malignant AML cells is a prerequisite for the development of therapeutic strategies employing miRNA modulators. Herein, we review the roles of emerging miRNAs and the miRNAs regulatory networks in AML pathogenesis, prognosis, and miRNA-directed therapies.
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