Journal
ONCOTARGET
Volume 7, Issue 32, Pages 51763-51772Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10107
Keywords
gastric cancer; long non-coding RNA; biomarker; HULC
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Funding
- National Nuture Science Foundation of China [81301498, 81271920]
- Jiangsu Provincial Program for Medical Innovation Teams and Leading Talents [LJ201133]
- Scientific research subject of Jiangsu province health department [H201422]
- Research project of Jiangsu provincial health and Family Planning Commission [H201526]
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Long non-coding RNAs (lncRNAs) have recently emerged as vital players in tumor biology with potential value in cancer diagnosis, prognosis, and therapeutics. The lncRNA HULC (highly up-regulated in liver cancer) is increased in many malignancies, yet its serum expression profile and clinical value in gastric cancer (GC) patients remain unclear. Quantitative real-time polymerase chain reaction (RT-qPCR) for large-scale analysis of the serum expression of HULC in GC patients reliably detected circulating HULC and revealed that it is upregulated in GC patients. A high serum HULC level correlated with tumor size, lymph node metastasis, distant metastasis, tumor-node-metastasis stage, and H. pylori infection. The area under the ROC curve for HULC was up to 0.888, which was higher than that for CEA (0.694) and CA72-4 (0.514). Follow-up detection and Kaplan-Meier curve analysis revealed HULC is a good predictor of GC prognosis. Our present study indicates that circulating HULC may represent a novel serum tumor marker for early diagnosis and monitoring progression and prognosis of GC.
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