Journal
ONCOTARGET
Volume 8, Issue 54, Pages 91817-91827Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11131
Keywords
STAMP2; ASC; lipogenesis; adipogenesis; prostate cancer
Categories
Funding
- Norwegian Research Council [193337]
- Norwegian Cancer Society [419204]
- South-Eastern Norway Regional Health Authority [2012070]
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Six Transmembrane Protein of Prostate 2 (STAMP2) has been implicated in both prostate cancer (PCa) and metabolic disease. STAMP2 has unique anti-inflammatory and pro-metabolic properties in mouse adipose tissue, but there is limited information on its role in human metabolic tissues. Using human adipose-derived stem cells (ASCs), we report that STAMP2 expression is dramatically upregulated during adipogenesis. shRNA-mediated STAMP2 knockdown in ASCs significantly suppresses adipogenesis and interferes with optimal expression of adipogenic genes and adipocyte metabolic function. Furthermore, ASC-derived adipocyte-mediated stimulation of prostate tumor growth in nude mice is significantly reduced upon STAMP2 knockdown in ASC adipocytes. These results suggest that STAMP2 is crucial for normal ASC conversion into adipocytes and their metabolic function, as well as their ability to facilitate PCa growth in vivo.
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