Journal
ONCOTARGET
Volume 7, Issue 13, Pages 15554-15565Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6952
Keywords
racdiation-induced fibrosis; alpha-lipoic acid; acetylation; NF-kappa B; PAJ-I
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MEST) [NRF-2012R1A2A2A01046062]
- Asan Institute for Life Sciences, Seoul, Korea [2014-308]
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Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that a-lipoic acid (a -LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of a -LA. alpha-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-131-mediated p300/CBP activity. Thus, alpha-LA prevents radiation-induced fibrosis (RIF) by inhibiting the transcriptional activity of NF -KB through inhibition of histone acetyltransferase activity. a -LA is a new therapeutic methods that can be used in the prevention-treatment of RIF.
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