Journal
CLINICAL NUTRITION
Volume 34, Issue 5, Pages 1010-1017Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2014.11.004
Keywords
Vitamin D; Middle-aged; Adiposity; Blood pressure; Fat mass; Inflammation
Categories
Funding
- Centre for Industrial Technological Development within National Strategic Consortia for Technical Research (Industrial Research diets and food with specific characteristics for elderly SENIFOOD)
- Linea Especial about Nutrition, Obesity and Health (University of Navarra) [LE/97]
- CIBERobn
- Asociacion de Amigos of the Universidad de Navarra
Ask authors/readers for more resources
Background & aims: The aim of this study is to further clarify the role of plasma 25(OH)D concentration after a weight-lowering nutritional intervention on body composition, blood pressure and inflammatory biomarkers in overweight/obese middle-aged subjects. Methods: This longitudinal research encompassed a total of 50 subjects [57.26 (5.24) year], who were under a 15% energy restricted diet for 4 weeks. Anthropometric and body composition variables, blood routine, inflammatory markers as well as 25(OH)D were analysed. Results: Circulating 25(OH)D levels [12.13(+/- 17.61%)] increased while anthropometric, body composition, routine blood markers as well as the concentration of TNF-alpha, C-reactive protein and Lp-PLA2 were significantly reduced after the intervention. Multiple linear regression analyses evidenced that Delta 25(OH) D increase was linked to the decrease in weight, adiposity, SBP and IL-6 levels. Moreover, a relationship was found between Delta 25(OH)D, Mat mass (r = -0.405; p = 0.007), ASBP (r = -0.355; p = 0.021) and Delta IL6 (r = -0.386; p = 0.014). On the other hand, a higher increase in 25(OH)D was accompanied by reductions in weight, BMI, SBP, IL-6 and an increase in bone mineral concentration (p < 0.05). Interestingly, higher levels of 25(OH)D at the endpoint, showed a significantly higher decrease in weight, BMI and total fat mass. Conclusions: The increase in plasma 25(OH)D level is linked with the decrease in SBP and adiposity in middle-aged subjects after a weight-loss intervention. Therefore, 25(OH)D assessment is a potential marker to be accounted in metabolic measures related to blood pressure, adiposity and inflammation in obesity management. Trial registration: www.clinicaltrials.gov (NCT01596309). (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available