Journal
ONCOTARGET
Volume 7, Issue 39, Pages 63661-63668Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11606
Keywords
c-type lectin-like receptor 2; clear cell renal cell carcinoma; prognostic factor; overall survival; recurrence-free survival
Categories
Funding
- National Key Projects for Infectious Diseases of China [2012ZX10002012-007, 2016ZX10002018-008]
- National Natural Science Foundation of China [31100629, 31270863, 81372755, 31470794, 81401988, 81402082, 81402085, 81471621, 81472227, 81472376, 31570803, 81501999, 81572352]
- Science and Technology Commission of Shanghai Municipality [14ZR 1406300]
- Program for New Century Excellent Talents in University [NCET-13-0146]
Ask authors/readers for more resources
We enrolled a total of 277 patients who received nephrectomy due to clear cell renal cell carcinoma (ccRCC) in Zhongshan Hospital from Jan 2005 to Jun 2007. Immunohistochemistry was performed to evaluate the impact of CLEC-2 positive cell infiltration on the overall survival (OS) and recurrence-free survival (RFS) of patients with ccRCC. Kaplan-Meier analysis showed that high CLEC-2 positive cell infiltration in tumor tissue indicated poorer OS and RFS (OS, p < 0.001; RFS, p = 0.002). High CLEC-2 positive cell infiltration is also an independent risk factor for OS and RFS in multivariate analyses (OS, p = 0.004; RFS, p = 0.009). CLEC-2 positive cell infiltration could also stratify ccRCC patients' survival with University of California Integrated Staging System (UISS) stratum in the mediate-risk and high-risk groups. We constructed two nomograms incorporating parameters derived from multivariate analyses to predict patients' OS and RFS (OS, c-index 0.813; RFS, c-index 0.716). In conclusion, high CLEC-2 positive cell infiltration in ccRCC is an independent adverse prognostic factor for patients, and established nomograms based on this information could help predict ccRCC patients' OS and RFS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available