Journal
ONCOTARGET
Volume 7, Issue 16, Pages 21235-21246Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6908
Keywords
autophagy; immune; cancer immunotherapy
Categories
Funding
- National Natural Science Foundation of China [81301891]
- Zhejiang province science and technology project of TCM [2015ZB033]
Ask authors/readers for more resources
Autophagy is an evolutionarily conserved catabolic process by which cellular components are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal degradation and recycling. Accumulating evidence suggests that autophagy plays a critical role in cell survival, senescence and homeostasis, and its dysregulation is associated with a variety of diseases including cancer, cardiovascular disease, neurodegeneration. Recent studies show that autophagy is also an important regulator of cell immune response. However, the mechanism by which autophagy regulates tumor immune responses remains elusive. In this review, we will describe the role of autophagy in immune regulation and summarize the possible molecular mechanisms that are currently well documented in the ability of autophagy to control cell immune response. In addition, the scientific and clinical hurdles regarding the potential role of autophagy in cancer immunotherapy will be discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available