Journal
ONCOTARGET
Volume 8, Issue 20, Pages 33844-33854Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.12953
Keywords
FGFR2; amplification; advanced gastric cancer; prognosis; quantitative real-time polymerase chain reaction
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Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI12C1785]
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Although Fibroblast growth factor receptor (FGFR) 2 gene amplification and its prognostic significance have been reported in resectable gastric cancers, information on these features remains limited in the metastatic setting. The presence of FGFR2 amplification was assessed in formalin-fixed, paraffin-embedded tissues using a quantitative PCR-based gene copy number assay with advanced gastric cancer cohorts. A total of 327 patients with tumor portion of >= 70% were analyzed for clinical features. Among these patients, 260 who received first-line fluoropyrimidine and platinum chemotherapy were analyzed for survival. Sixteen of 327 patients (4.9%) exhibited FGFR2 amplification. The amplification group showed associations with age <65 years, Borrmann type 4 disease, poor performance status, poorly differentiated histology, extra-abdominal lymph node metastases, and bone metastases. The median overall survival (OS) and progressionfree survival (PFS) were found to be 12.7 and 5.8 months, respectively. In univariate analysis, PFS did not differ between amplification and no amplification groups (hazard ratio [HR]= 1.34, 95% confidence interval [CI]: 0.78-2.31, p= 0.290), although the OS was significantly shorter in the amplification group (HR= 1.92, 95% CI: 1.13-3.26, p= 0.015). However, multivariate analysis indicated that FGFR2 amplification was not an independent prognostic factor for OS (HR= 1.42, 95% CI: 0.77-2.61, p= 0.261). Although FGFR2 amplification is associated with poorer OS, it does not appear to be an independent prognostic predictor in patients with advanced gastric cancer treated with palliative fluoropyrimidine and platinum chemotherapy.
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