Journal
NUTRIENTS
Volume 8, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/nu8010010
Keywords
in-vitro fertilization; weight loss; diet; exercise; pregnancy; fertility; assisted reproductive technology; unsaturated fat; omega 3 fatty acids
Categories
Funding
- NHMRC
- Brailsford Robertson Grant
- University of Adelaide in Adelaide, Australia
- Novartis USA
- South Australian Cardiovascular Research Development Program Fellowship
- National Heart Foundation
- South Australian Department of Health
- South Australian Health and Medical Research Institute
Ask authors/readers for more resources
Maternal preconception diet is proposed to affect fertility. Prior research assessing the effect of altering the fatty acid profile on female fertility is conflicting. The aim of this study was to assess the effect of preconception maternal diet, specifically fatty acid profile, on pregnancies and live births following in vitro fertilisation (IVF). Forty-six overweight and obese women undergoing IVF were randomised to a diet and physical activity intervention (intervention) or standard care (control). Outcome measures included pregnancy, live birth and pre-study dietary intake from food frequency questionnaire. Twenty pregnancies (n = 12/18 vs. n = 8/20, p = 0.12) and 12 live births (n = 7/18 vs. n = 5/20, p = 0.48) occurred following the intervention with no differences between the treatment groups. On analysis adjusted for BMI and smoking status, women who became pregnant had higher levels of polyunsaturated fatty acid (PUFA) intake (p = 0.03), specifically omega-6 PUFA and linoleic acid (LA) (p = 0.045) with a trend for an elevated intake of omega-3 PUFA (p = 0.06). There were no dietary differences for women who did or did not have a live birth. Maternal preconception PUFA, and specifically omega-6 and LA intake, are associated with improved pregnancy rates in overweight and obese women undergoing IVF. This has implications for optimising fertility through preconception nutrition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available