Journal
NPG ASIA MATERIALS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/am.2016.80
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Funding
- National Research Foundation of Korea [NRF-2013R1A1A1061387]
- KU-KIST research fund, a National Research Foundation of Korea (NRF) grant - Korean Government (MEST) [2009-0078234]
- National Nuclear R&D Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012M2A2A7014020]
- Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A111345]
- Medical Cluster R&D Support Project of Daegu Gyeong-buk Medical Innovation Foundation
- National Research Foundation of Korea (NRF) Grant - Korean Government (MSIP) [2014R1A1A1003323]
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2009-0078234, 2009-0078222, NRF-2015M2A2A7A01045177]
- Korea Health technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI16C1501]
- Medical Cluster R&D Support Project through the Daegu-Gyengbuk Medical Innovation Foundation (DGMIF) - Ministry of Health Welfare [HT13C0002]
- BK21 PlusKNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, National Research Foundation of Korea (NRF) grant - Korea Government (MSIP) [2014R1A1A1003323]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare [HI15C0001]
- Radiation Technology R&D program through the National Research Foundation of Korea - Ministry of Science, ICT & Future Planning [NRF-2012M2A2A7013480]
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Radionuclide-embedded gold nanoparticles (RIe-AuNPs) were developed as a highly sensitive and stable nuclear and optical imaging agent for efficient dendritic cell (DC)-based immunotherapy and sensitive tracking of DC-migration to lymph nodes. The RIe-AuNPs were synthesized via simple and straightforward DNA-based radiolabeling chemistry and additional Au shell formation strategies, leading to high radiosensitivity and excellent in vivo stability. The RIe-AuNPs exert no adverse effects on the biological functions of DCs, and labeled DCs show strong antitumor immunity for lung cancer. Furthermore, the high radiosensitivity of the RIe-AuNPs allows for sensitive and long-term monitoring of DC migration to draining lymph nodes. The developed Cerenkov radiation-based optical imaging approach provides quantitative and sensitive results comparable with that of positron emission tomography imaging. These results highlight the strong potential of the RIe-AuNPs as a highly sensitive and stable nuclear and optical imaging platform for future bioimaging application such as cell tracking and tumor imaging.
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