Journal
NEUROSCIENCE BULLETIN
Volume 33, Issue 3, Pages 339-347Publisher
SPRINGER
DOI: 10.1007/s12264-016-0094-x
Keywords
Electroconvulsive therapy; Neurotransmitters; Neurotrophins; Inflammatory factors; Epigenetics; Neuroimaging
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Funding
- Shanghai Hospital Development Center, China [SHDC12014111]
- Science and Technology Commission of Shanghai Municipality, China [14411961400, 13dz2260500]
- Shanghai Health System Leadership in Health Research Program, China [XBR2011005]
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In spite of the extensive application of electroconvulsive therapy (ECT), how it works remains unclear. So far, researchers have made great efforts in figuring out the mechanisms underlying the effect of ECT treatment via determining the levels of neurotransmitters and cytokines and using genetic and epigenetic tools, as well as structural and functional neuroimaging. To help address this question and provide implications for future research, relevant clinical trials and animal experiments are reviewed.
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