Journal
NEUROSCIENCE BULLETIN
Volume 33, Issue 3, Pages 307-311Publisher
SPRINGER
DOI: 10.1007/s12264-016-0079-9
Keywords
Schizophrenia; Cortical plasticity; Motor learning; human
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Funding
- Program of Medical Science of Ningbo Municipality, Zhejiang Province, China [2013A23]
- Ningbo Municipal Innovation Team of Life Science and Health, Zhejiang Province, China [2015C110026]
- National Natural Science Foundation of China [81501164, 81611130224]
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Patients with schizophrenia undergo changes in brain plasticity. In the present study, we characterized motor cortical-striatal plasticity in such patients. Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group, the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles. Notably, the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task. Moreover, the loss of plasticity was correlated with the symptoms of schizophrenia. The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning.
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