Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 23, Issue 5, Pages 456-458Publisher
NATURE PORTFOLIO
DOI: 10.1038/nsmb.3213
Keywords
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Funding
- Emergency Task-Force Project of the National Natural Science Foundation of China (NSFC) [81641001]
- China Ministry of Science and Technology National 973 Project [2015CB910500]
- Task Force of Zika Virus Research from the Chinese Academy of Sciences (CAS)
- Zika Special Project of the National Infectious Disease Control ST Grand Project
- Strategic Priority Research Program of the CAS [XDB08020100]
- Excellent Young Scientist Program of the CAS
- Youth Innovation Promotion Association, CAS [2015078]
- NSFC Innovative Research Group [81321063]
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The association of Zika virus (ZIKV) infections with microcephaly has resulted in an ongoing public-health emergency. Here we report the crystal structure of a C-terminal fragment of ZIKV nonstructural protein 1 (NS1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis and immune evasion. Comparison with West Nile and dengue virus NS1 structures reveals conserved features but diverse electrostatic characteristics at host-interaction interfaces, thus possibly implying different modes of flavivirus pathogenesis.
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