Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 23, Issue 8, Pages 755-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3252
Keywords
-
Funding
- Cancer Research UK PhD Studentship
- Cancer Research UK [A17201]
- Medical Research Council
- University of Oxford
- EMBO Young Investigator Programme
- Cancer Research UK [17201, 23969] Funding Source: researchfish
Ask authors/readers for more resources
The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication-fork stability and homologous recombination (HR) DNA repair. Here we report that human cancer cells lacking BRCA2 rely on the Fanconi anemia protein FANCD2 to limit replication-fork progression and genomic instability. Our results identify a new role of FANCD2 in limiting constitutive replication stress in BRCA2-deficient cells, thereby affecting cell survival and treatment responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
