Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 23, Issue 6, Pages 494-502Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3214
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Funding
- NIGMS [P41-GM103311]
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Ion channels gated by neurotransmitters are present across metazoans, in which they are essential for brain function, sensation and locomotion; closely related homologs are also found in bacteria. Structures of eukaryotic pentameric cysteine-loop (Cys-loop) receptors and tetrameric ionotropic glutamate receptors in multiple functional states have recently become available. Here, I describe how these studies relate to established ideas regarding receptor activation and how they have enabled decades' worth of functional work to be pieced together, thus allowing previously puzzling aspects of receptor activity to be understood.
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