Journal
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
Volume 8, Issue 2, Pages 216-225Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S2040174416000623
Keywords
autonomic control; hypertension; offspring; westernized diet
Categories
Ask authors/readers for more resources
The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother's diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram. Cardiovascular parameters were measured on the same period. Autonomic nervous system modulation was evaluated by spectrum analysis of heart rate (HR) and systolic arterial pressure (SAP). The W increased glycemia (123 +/- 2 v. 155 +/- 2 mg/dl), low-density lipoprotein (15 +/- 1 v. 31 +/- 2 mg/dl), triglycerides (49 +/- 1 v. 85 +/- 2 mg/dl), total cholesterol (75 +/- 2 v. 86 +/- 2 mg/dl), and decreased high-density lipoprotein (50 +/- 4 v. 38 +/- 3 mg/dl), as well as increased body mass (209 +/- 4 v. 229 +/- 6 g) than C. Furthermore, the W showed higher SAP (130 +/- 4 v. 157 +/- 2 mmHg), HR (357 +/- 10 v. 428 +/- 14 bpm), sympathetic modulation to vessels (2.3 +/- 0.56 v. 6 +/- 0.84 mmHg(2)) and LF/HF ratio (0.15 +/- 0.01 v. 0.7 +/- 0.2) than C. These findings suggest that a western diet during pregnancy and lactation leads to overweight associated with autonomic misbalance and hypertension in adulthood.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available