Journal
CLINICAL NUCLEAR MEDICINE
Volume 40, Issue 9, Pages 727-729Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RLU.0000000000000851
Keywords
Psoriasis; skin; fluorodeoxyglucose; positron emission tomography; non-attenuation corrected; attenuation corrected
Funding
- NHLBI NIH HHS [R01 HL111293] Funding Source: Medline
- NIAMS NIH HHS [2T32 AR 7465-31, K24 AR064310, K24-AR064310, T32 AR007465] Funding Source: Medline
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Psoriasis is a chronic inflammatory skin condition characterized by well-circumscribed erythematous plaques with thick silvery scale. Infiltration of inflammatory cells such as lymphocytes, neutrophils, and macrophages and epidermal cell proliferation within psoriatic lesions may result in selective FDG accumulation. We present a 55-year-old patient with a 30-year history of psoriasis. Nonattenuation corrected PET/CT images demonstrated significant cutaneous FDG uptake corresponding to clinically apparent psoriatic lesions. However, in attenuation corrected (AC) FDG-PET images, the signal was substantially diminished and minimally detectable. Nonattenuation corrected FDG-PET images may be useful and preferable to AC images in assessing skin inflammation in psoriasis.
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