Journal
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
Volume -, Issue -, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/database/baw093
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Funding
- Wellcome Trust [WT095908, WT098051]
- National Human Genome Research Institute [U54HG004555, U41HG007234, 1R01HD074078]
- Biotechnology and Biological Sciences Research Council [BB/M011615/1, BB/I025506/1, BB/I025360/1, BB/I025360/2, BB/M011461/1, BB/K009524/1, BB/M018458/1, BBS/B/13446, BBS/B/13470, BB/E011640/1]
- European Molecular Biology Laboratory
- BBSRC [BB/I025360/2, BB/I025506/1, BB/M011461/1, BB/K009524/1, BB/M018458/1, BB/I025360/1, BB/E011640/1, BB/M011615/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M011461/1, BB/I025506/1, BB/M011615/1, BB/I025360/1, BB/M018458/1, BB/I025360/2, BBS/B/13470, BB/K009524/1, BBS/B/13446, BB/E011640/1] Funding Source: researchfish
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The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is based on the alignment of biological sequences, including cDNAs, proteins and RNA-seq reads, to the target genome in order to construct candidate transcript models. Careful assessment and filtering of these candidate transcripts ultimately leads to the final gene set, which is made available on the Ensembl website. Here, we describe the annotation process in detail.
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