Journal
CELL ADHESION & MIGRATION
Volume 11, Issue 2, Pages 127-134Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2016.1251000
Keywords
aging; autophagy; endosomes; exosomes; extracellular vesicles; homeostasis; inflammation; lysosome; multivesicular bodies; proteostasis
Categories
Funding
- Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III [CP 14/00219]
- Fondo Europeo de Desarrollo Regional (FEDER)
Ask authors/readers for more resources
Due to their ability to shuttle proteins, lipids and genetic material between distant cells, exosomes promote extensive phenotypic changes in recipient cells, modulating immune responses, cellular migration, cancer metastasis or the spreading of neurotoxic protein aggregates in neurodegenerative diseases. Besides intercellular communication, exosome biogenesis and secretion permit the rapid release of a selective repertoire of compounds, conferring cells with an additional mechanism to fight alterations in protein, lipid or RNA homeostasis during stress or pathological conditions. Here, we review the dual role of the different quality control mechanisms arising from the endolysosomal system and the diverse situations that control the decision between degradation or secretion. The crosstalk between exosome secretion and the different cellular degradation mechanisms confers an additional layer of protection to maintain cellular integrity and homeostasis in a number of physiological and pathological conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available